Takdir Tahir, Nurdiana Djamaluddin, Abdul Thalib, Maryunis Maryunis, Saldy Yusuf, Fifi Riskayani, Fitria Fitria
The red dragon fruit (Hylocereus polyrhizus) extract (RDFE) is frequently used for a variety of therapeutic purposes (e.g., boosting the immune system, promoting a healthy gastrointestinal system, improving wound healing). We investigated the effects of a topical cream containing 7.5% RDFE on hydroxyproline and fibroblast growth factor 2 (FGF-2) levels and wound healing. On Day 0, we divided a total of 36 albino male Wistar rats into two equal groups. Using an 8-mm punch biopsy, we created a circular excision to fascial depth on the back of each rat. On Day 1, we treated the control group (n = 18) with 20 mg of base cream and the RDFE group (n = 18) with 20 mg of 7.5% RDFE cream. We measured hydroxyproline and FGF-2 levels in the wound tissue using an ELISA method on Days 3, 7, and 14. We found that on Day 3, hydroxyproline levels were significantly lower in the treatment group than in the control group (p =.031). We also found a significant correlation between FGF-2 levels in the treatment group and wound diameter (p =.02). On the basis of the results of this study, we concluded that using a topical cream containing 7.5% RDFE has the potential to accelerate wound healing by increasing levels of hydroxyproline and FGF-2 in the wound. Copyright © 2023 International Society of Plastic and Aesthetic Nurses. All rights reserved.
The Department of Medical-Surgical Nursing, Hasanuddin University, Makassar, Indonesia; The Department of Medical-Surgical Nursing, Gorontalo State University, Indonesia; The Department of Medical-Surgical Nursing, School of Nursing, Pasapua Ambon, Indonesia; The Department of Medical-Surgical Nursing, University of Muslim Indonesia, Indonesia; The Dharmais National Cancer Hospital, Jakarta, Indonesia; The Labuang Baji Regional General Hospital, Makassar, Indonesia
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