Agus Rusdin, Amirah Mohd Gazzali, Nur Ain Thomas, Sandra Megantara, Diah Lia Aulifa, Arif Budiman, Muchtaridi Muchtaridi
Background: The current challenge in drug development lies in addressing the physicochemical issues that lead to low drug effectiveness. Solubility, a crucial physicochemical parameter, greatly influences various biopharmaceutical aspects of a drug, including dissolution rate, absorption, and bioavailability. Amorphous solid dispersion (ASD) has emerged as a widely explored approach to enhance drug solubility. Objective: The objective of this review is to discuss and summarize the development of polyvinylpyrrolidone (PVP)-based amorphous solid dispersion in improving the physicochemical properties of drugs, with a focus on the use of PVP as a novel approach. Methodology: This review was conducted by examining relevant journals obtained from databases such as Scopus, PubMed, and Google Scholar, since 2018. The inclusion and exclusion criteria were applied to select suitable articles. Results: This study demonstrated the versatility and efficacy of PVP in enhancing the solubility and bioavailability of poorly soluble drugs. Diverse preparation methods, including solvent evaporation, melt quenching, electrospinning, coprecipitation, and ball milling are discussed for the production of ASDs with tailored characteristics. Conclusion: PVP-based ASDs could offer significant advantages in the formulation strategies, stability, and performance of poorly soluble drugs to enhance their overall bioavailability. The diverse methodologies and findings presented in this review will pave the way for further advancements in the development of effective and tailored amorphous solid dispersions. © 2024 by the authors.
Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjadjaran, Jl. Raya Bandung-Sumedang Km-21, Bandung, 45363, Indonesia; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjadjaran, Jl. Raya Bandung-Sumedang Km-21, Bandung, 45363, Indonesia; Departement Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, P.Penang, 11800, Malaysia; Department of Pharmacy, Faculty of Sport and Health, Universitas Negeri Gorontalo, Jl. Jenderal Sudirman No. 6, Gorontalo, 96128, Indonesia; Research Collaboration Centre for Theranostic Radiopharmaceuticals, National Research and Innovation Agency (BRIN), Jakarta Pusat 10340, Indonesia
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