Mohamad Aprianto Paneo, Endah Nurrohwinta Djuwarno, Sitty Ainsyah Habibie, Nurain Thomas, Multiani S. Latif, Nur Alifia Karina Munafri, Rayhan Firman Anasiru
This study aimed to evaluate the efficacy of different concentrations of Hulu’u fish albumin-based spray gels in promoting wound healing in burn injuries in male white rats. The formulations included 10%, 15%, and 20% concentrations of Hulu’u fish albumin, which were compared to a commercial snakehead fish albumin gel (positive control) and a spray gel base without albumin (negative control). Wound diameter reduction was assessed over seven days. The results indicated a clear dose response relationship, with the 20% Hulu’u fish albumin formulation (F3) achieving the most significant reduction in wound diameter, averaging 1.57 mm (range: 1.5–1.6 mm), representing a 91.8% improvement compared to the negative control group, which showed an average reduction of 19.13 mm (range: 18.1–19.7 mm). The Positive Control (snakehead fish albumin gel) demonstrated a moderate reduction with an average of 6.97 mm (range: 6.6–7.6 mm). The 10% Hulu’u fish albumin (F1) and 15% Hulu’u fish albumin (F2) formulations showed moderate improvements, with average reductions of 4.73 mm (range: 4.4–5.1 mm) and 4.5 mm (range: 4.7–3.9 mm), respectively. These findings suggest that higher concentrations of Hulu’u fish albumin, particularly the 20% formulation, offer superior wound healing properties, outperforming both the negative control and the commercial snakehead fish albumin gel. The study highlights the potential of Hulu’u fish albumin as a novel bioactive compound for burn wound treatment and warrants further investigation for clinical applications. © 2026 The Authors.
Department of Pharmacy, Faculty of Sport and Health, Universitas Negeri Gorontalo, Gorontalo, 96128, Indonesia; Department of Aquatic Resources Management Faculty of Marine Affairs and Fisheries Technology, Universitas Negeri Gorontalo, Gorontalo, 96128, Indonesia
Research at a Glance
Register to unlock
Topics & SDG Alignment
Register to unlock
Collaboration
Register to unlock
Author Profile (Selected)
Register to unlock
References Overview
Register to unlock
Journal & Source
Register to unlock
Metadata & Integrity
Register to unlock