Nasrul Wathoni, Agus Rusdin, Erma Febriani, Destiana Purnama, Wahnidar Daulay, Sundoro Azhary, Camellia Panatarani, I. Joni, Ronny Lesmana, Keiichi Motoyama, Muchtaridi Muchtaridi
Context: mangostin, one of the xanthone derivative compounds isolated from Garcinia mangostana L. peel extract, has an excellent anticancer efficacy. However, mangostin has a lack of site specificity, poor cells selectivity, and low aqueous solubility. Polymeric nanoparticles formulation can be used to solve these problems. Aim: Therefore, the main aim of this study was to develop polymeric nanoparticles of mangostin-based chitosan (M-Ch) coated by sodium alginate (M-Ch/Al), sodium silicate (M-Ch/Si), and polyethylene glycol 6000 (M-Ch/PEG). Materials and Methods: Polymeric nanoparticles were prepared by ionic gelation method with the spray pyrolysis technique. Optimized formula was characterized by scanning electron microscopy, particle size, entrapment efficiency, drug loading, Fourier transform infrared, X-ray diffraction (XRD), and differential scanning calorimetry (DSC). Results: M-Ch/Al, M-Ch/Si, and M-Ch/PEG Nanoparticles were successfully prepared with the range of particle size approximately 200-400nm. The XRD patterns and DSC thermograms of M-Ch/Al showed an amorphous state, whereas M-Ch/Si and M-Ch/PEG indicated low crystalline forms. In addition, M-Ch/Al had the highest entrapment efficiency (98.33% ± 0.06%) compared to M-Ch/Si (70.46% ± 8.93%), and M-Ch/PEG (92.24% ± 10.98%). Conclusion: These results suggest that M-Ch/Al has the potential to enhance the physicochemical properties of mangostin for further formulation as an anticancer agent. © 2019 Journal of Pharmacy and Bioallied Sciences | Published by Wolters Kluwer - Medknow.
Department of Pharmaceutics, Faculty of Pharmacy, Padjadjaran University, Sumedang, 45363, Indonesia; Department of Pharmacy, Faculty of Sports and Health, Universitas Negeri Gorontalo, Gorontalo, Indonesia; Department of Physics, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Sumedang, Indonesia; Department of Anatomy, Physiology and Biology Cell Faculty of Medicine, Padjadjaran University, Sumedang, Indonesia; School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Padjadjaran University, Sumedang, Indonesia
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